Der Anaesthesist
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Randomized Controlled Trial
[Tonsillotomy and adenotonsillectomy in childhood. Study on postoperative pain therapy].
The primary aim of this study was to determine whether the combination of i.v. ketoprofen and i.v. paracetamol provides superior postoperative analgesia in children undergoing adenoidectomy or tonsillotomy compared to either drug alone. The secondary goal was to assess the time until rescue analgesia was needed, propofol requirements and the incidence of vomiting and time of discharge from the postanaesthesia recovery unit (PARU). ⋯ The combination of i.v. paracetamol and i.v. ketoprofen provides superior postoperative analgesia compared to the single use of paracetamol.
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Randomized Controlled Trial
Hemodynamics in coronary artery bypass surgery: effects of intraoperative dexmedetomidine administration.
Dexmedetomidine is an α2-receptor agonist which is increasingly being used in coronary artery bypass grafting (CABG) surgery due to its suppressive effect on the stress responses against intubation and surgery. In this study effects of dexmedetomidine administration as an adjuvant agent during induction and maintenance of anesthesia on intraoperative hemodynamic changes were studied in patients undergoing CABG. ⋯ Dexmedetomidine can be safely used in CABG operations delivering a stable hemodynamic status throughout the operative period.
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Randomized Controlled Trial Multicenter Study
[Implementation of new standards in anaesthesia. Exemplified by the ad hoc introduction of desflurane in 10 German hospitals].
According to numerous pharmacoeconomic studies new anaesthesia techniques can improve recovery times and thus can have a positive economic impact on patient turnover. However, artificial study protocols do not always match real world situations and thus the practical impact of such studies remains unclear. ⋯ The implementation of a new drug (here: desflurane to substitute sevoflurane) can improve speed of recovery immediately after termination of anaesthesia even after a very short period of introducing the new technique but has no positive long term effects. Thus, the results of this trial performed under a real world scenario (health service research) without tight standardization by an artificial study protocol supports the results originating from randomized controlled clinical trials.
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Randomized Controlled Trial
Spontaneously breathing anesthetized patients with a laryngeal mask airway: positive end-expiratory pressure does not improve oxygen saturation.
Spontaneous ventilation is a popular mode of ventilation for patients with the laryngeal mask airway (LMA). Studies have shown, however, that spontaneous ventilation impairs gas exchange and that assisting or controlling ventilation results in higher oxygen saturation. Atelectasis during general anesthesia is a well described mechanism which impacts on gas exchange. ⋯ The application of a PEEP of +7 cm H₂O with a LMA under spontaneous ventilation cannot be recommended. Limitations of our study were the selection of healthy patients and omitting pre-oxygenation before induction which might have limited the development of atelectasis. In addition arterial partial pressure of oxygen (p(a)O₂) measurements could have revealed subtle changes in oxygenation.
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Randomized Controlled Trial
Hyperbaric levobupivacaine in anal surgery : Spinal perianal and spinal saddle blocks.
An ideal anesthetic technique for anal surgery on an outpatient basis should permit early mobilization without pain or residual complications of anesthesia. The aim of this study was to analyze the reliability and efficacy of spinal perianal and spinal saddle block by using two different doses of levobupivacaine for perianal surgery and their effects on voiding, first analgesic requirement and hospital discharge times. ⋯ The results of the study showed that the use of 1.5 mg hyperbaric levobupivacaine provides sufficient and satisfactory anesthesia in ambulatory perianal surgery.