Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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Acad Emerg Med
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Comparative Study
Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model.
Recent animal studies have shown that intravenous fat emulsion (IFE) increases survival and hemodynamics in severe verapamil toxicity. However, the optimal dose of IFE is unknown. The primary objective was to determine the optimal dose of IFE based on survival in severe verapamil toxicity. Secondary objectives were to determine the effects on hemodynamic and metabolic parameters. The hypothesis was that there is a dose-dependent effect of IFE on survival until a maximum dose is reached. ⋯ The greatest benefit to survival occurs with 18.6 mL/kg IFE, while the greatest benefit to HR, MAP, and BE occurs at 24.8 mL/kg IFE. The optimal dose for the treatment of severe verapamil toxicity in this murine model was 18.6 mL/kg.
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Editorial Biography Historical Article
Michelle H. Biros, MD, MS, completes 10 years as editor-in-chief of Academic Emergency Medicine.