American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Sep 2011
ReviewCurrent controversies and future perspectives in chronic obstructive pulmonary disease.
Over the past decade there has been much research and interest in COPD. As a result, the understanding and management of the disease has improved significantly. Yet, there are many uncertainties and controversies that require further work. This review discusses these controversies and anticipates some of the changes that may occur in the near future in the field of COPD.
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Am. J. Respir. Crit. Care Med. · Sep 2011
Comparative StudyFas determines differential fates of resident and recruited macrophages during resolution of acute lung injury.
During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. ⋯ These findings indicate that Fas-induced apoptosis of recruited macrophages is essential for complete resolution of ALI.