Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
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Neurogastroenterol. Motil. · Jun 2020
Randomized Controlled TrialAcupuncture of different treatment frequency in postprandial distress syndrome: A pilot randomized clinical trial.
The evidence for different frequencies of acupuncture treatment in postprandial distress syndrome (PDS) is insufficient. This study determined whether 3 sessions per week of acupuncture treatment are superior to 1 session per week for symptomatic outcomes in PDS. ⋯ This trial showed that acupuncture, at 3 sessions per week, tended to improve symptoms and the quality of life among patients with PDS as compared to once a week. Acupuncture treatment for 4 weeks was feasible and safe. A larger sample, multicenter, randomized controlled trial of acupuncture for PDS appears to be justified in the future.
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Neurogastroenterol. Motil. · May 2020
Randomized Controlled TrialAnodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia.
Dysphagia in the elderly, known as presbydysphagia, has become a relevant public health problem in several countries. Swallowing disorders may be a consequence of different neurological disorders (secondary presbydysphagia) or the expression of the aging process itself (primary presbydysphagia). We aimed to test the therapeutic potential of two different non-invasive brain stimulation (NIBS) techniques in subjects with primary or secondary presbydysphagia. ⋯ Our results suggest that non-invasive cortical stimulation may be useful for dysphagia recovery in elderly patients.
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Neurogastroenterol. Motil. · Feb 2019
Randomized Controlled TrialTranscutaneous electrical acustimulation synchronized with inspiration improves gastric accommodation impaired by cold stress in healthy subjects.
The aim of this study was to investigate whether transcutaneous electrical acustimulation (TEA) synchronized with inspiration (STEA), a method known to enhance vagal activity, was more effective than TEA in improving cold stress-induced impairment in gastric accommodation (GA) and dyspeptic symptoms in healthy subjects. ⋯ TEA synchronized with inspiration is more potent than TEA in improving cold stress-induced impairment in GA and GSW and dyspeptic symptoms and might be a novel noninvasive therapy for treating stress-induced dysmotility and dyspeptic symptoms.
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Neurogastroenterol. Motil. · Jan 2019
Randomized Controlled TrialHigh-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan.
A previous phase II dose-ranging study of linaclotide in a Japanese chronic constipation (CC) population showed that 0.5 mg was the most effective dose. This study aimed to verify the hypothesis that 0.5 mg of linaclotide is effective and safe in Japanese CC patients. ⋯ The results of this study indicate that a linaclotide dose of 0.5 mg/day is effective and safe in Japanese CC patients.
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Neurogastroenterol. Motil. · Dec 2018
Randomized Controlled Trial Multicenter StudyA randomized controlled and long-term linaclotide study of irritable bowel syndrome with constipation patients in Japan.
Clinical testing was required to verify the effect of linaclotide 0.5 mg/d in patients with irritable bowel syndrome with constipation (IBS-C) in Japan. ⋯ This study suggests that a linaclotide dose of 0.5 mg is effective and safe for IBS-C patients in Japan.