Archives of disease in childhood. Fetal and neonatal edition
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2013
Randomized Controlled TrialAxillary temperature measurement during hypothermia treatment for neonatal hypoxic-ischaemic encephalopathy.
To determine the accuracy of axillary temperature relative to core rectal temperature during whole-body therapeutic hypothermia for moderate-to-severe hypoxic-ischaemic encephalopathy. ⋯ As there is wide variability in the difference between axillary and rectal temperatures at all stages of whole-body cooling, our data do not support the use of axillary temperature as a surrogate for core rectal temperature during therapeutic hypothermia.
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 2012
Randomized Controlled Trial Comparative StudyRandomised weaning trial comparing assist control to pressure support ventilation.
To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning. ⋯ No significant differences were found between weaning by PSV and ACV when similar inflation times were used.
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 2012
Randomized Controlled TrialBrain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy.
The objective of our study was to examine the relationship between brain injury and outcome following neonatal hypoxic-ischaemic encephalopathy treated with hypothermia. ⋯ Fewer areas of infarction and a trend towards more normal scans were noted in brain MRI following whole-body hypothermia. Presence of the NICHD pattern of brain injury is a marker of death or moderate or severe disability at 18-22 months following hypothermia for neonatal encephalopathy.
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Arch. Dis. Child. Fetal Neonatal Ed. · Mar 2012
Randomized Controlled TrialNitrous oxide analgesia during retinopathy screening: a randomised controlled trial.
To determine if the addition of an inhaled equimolar mixture of nitrous oxide (N(2)O) and oxygen (EMONO) would produce superior pain relief to standard pharmacological and non-pharmacological measures during eye examination screening for retinopathy of prematurity (ROP) in premature infants. ⋯ EMONO does not produce any additional pain relief over currently used measures during ROP screening eye examinations. Systematically combining pharmacological and non-pharmacological treatment modalities appears to be the best option until newer treatments are proven effective.
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Arch. Dis. Child. Fetal Neonatal Ed. · Jan 2012
Randomized Controlled Trial Comparative StudyEfficacy of tramadol versus fentanyl for postoperative analgesia in neonates.
To assess, in newborn infants submitted to surgical procedures, the efficacy of two opioids-fentanyl and tramadol-regarding time to extubate, time to achieve 100 ml/kg of enteral feeding and pain in the first 72 h after surgery. ⋯ Tramadol was as effective as fentanyl for postoperative pain relief in neonates but does not appear to offer advantages over fentanyl regarding the duration of mechanical ventilation and time to reach full enteral feeding. Trial registration NCT00713726.