Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Ann. Allergy Asthma Immunol. · Jul 2001
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.
There are no studies on the use of cetirizine in children under the age of 6. ⋯ The results of the present study suggest that cetirizine may represent an effective and safe pharmacologic therapy for chronic urticaria in preschool children. There was no evidence for changes in hematochemical and urinary values, demonstrating the safety and the tolerability of the two antihistamines, even when given to young children.
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Ann. Allergy Asthma Immunol. · Jun 2001
Randomized Controlled Trial Multicenter Study Clinical TrialOnce-daily budesonide via Turbuhaler improves symptoms in adults with persistent asthma.
Previous studies have demonstrated the efficacy and safety of twice-daily budesonide Turbuhaler (Pulmicort Turbuhaler, AstraZeneca, Wilmington, DE) for the treatment of mild to severe asthma. ⋯ Budesonide Turbuhaler 400 microg administered once daily in the AM is efficacious and safe for inhaled corticosteroid-naive asthmatic adults.
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Ann. Allergy Asthma Immunol. · May 2000
Randomized Controlled Trial Multicenter Study Clinical TrialFexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria.
Fexofenadine is a nonsedating antihistamine approved for treatment of seasonal allergic rhinitis. ⋯ Fexofenadine HCl significantly reduced pruritus severity, number of wheals, and interference with sleep and normal daily activities in patients with chronic urticaria compared with placebo. Twice-daily doses of 60 mg or greater were most effective.
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Ann. Allergy Asthma Immunol. · Mar 1999
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialInhaled salmeterol and fluticasone: a study comparing monotherapy and combination therapy in asthma.
The current stepwise approach to pharmacotherapy in the treatment of asthma includes the initiation of an inhaled corticosteroid with the addition of a long-acting inhaled bronchodilator if low dose inhaled corticosteroid fails to control asthma symptoms. ⋯ Initiation of maintenance therapy with salmeterol and fluticasone propionate in patients with asthma treated with short-acting beta2-agonists alone provides greater improvements in pulmonary function and symptom control than initiation of maintenance therapy with fluticasone propionate alone.
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Ann. Allergy Asthma Immunol. · May 1997
Randomized Controlled Trial Multicenter Study Clinical TrialSalmeterol versus theophylline in the treatment of asthma.
Although theophylline is recommended by current guidelines for the management of asthma in patients with persistent symptoms, theophylline has a narrow therapeutic index, requiring individual dose titration and regular monitoring of serum theophylline concentrations to avoid adverse effects. ⋯ Salmeterol, 42 mg twice daily, was better tolerated and significantly more effective than extended-release theophylline twice daily in the maintenance treatment of asthma.