Annals of internal medicine

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• Ann. Intern. Med. · Feb 2021

  In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon β-1a differed from standard care for in-hospital mortality.

  Pan H, Peto R, Henao-Restrepo AM, et al. Repurposed antiviral drugs for Covid-19-interim WHO Solidarity Trial results. N Engl J Med. 2020. [Epub ahead of print.] 33264556.

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• Ann. Intern. Med. · Feb 2021

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  In CKD, dapagliflozin reduced a composite of eGFR decline, end-stage kidney disease, or CV or renal mortality.

  Heerspink HJ, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383:1436-46. 32970396.

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• Ann. Intern. Med. · Feb 2021

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  In adults hospitalized with COVID-19, the quick COVID-19 Severity Index predicted 24-h respiratory decompensation.

  Haimovich AD, Ravindra NG, Stoytchev S, et al. Development and validation of the quick COVID-19 Severity Index: a prognostic tool for early clinical decompensation. Ann Emerg Med. 2020;76:442-53. 33012378.

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• Ann. Intern. Med. · Feb 2021

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  Fluoroquinolones vs. amoxicillin-clavulanate or ampicillin-sulbactam were not linked to aortic aneurysm or dissection.

  Dong YH, Chang CH, Wang JL, et al. Association of infections and use of fluoroquinolones with the risk of aortic aneurysm or aortic dissection. JAMA Intern Med. 2020;180:1587-95. 32897358.

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• Ann. Intern. Med. · Feb 2021

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  After TAVI, aspirin vs. aspirin + clopidogrel for 3 mo reduced bleeding and a composite of bleeding and thrombotic events at 1 y.

  Brouwer J, Nijenhuis VJ, Delewi R, et al. Aspirin with or without clopidogrel after transcatheter aortic-valve implantation. N Engl J Med. 2020;383:1447-57. 32865376.

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