Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. ⋯ National Heart, Lung, and Blood Institute.
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Randomized Controlled Trial
In older inpatients with polypharmacy, medication optimization did not improve outcomes at 48 wk.
Ie K, Hirose M, Sakai T, et al. Medication optimization protocol efficacy for geriatric inpatients: a randomized clinical trial. JAMA Netw Open. 2024;7:e2423544. 39078632.
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Randomized Controlled Trial Multicenter Study
Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) led to new guidelines for statin use among people with HIV (PWH) with low to moderate risk for atherosclerotic cardiovascular disease (ASCVD). Little is known about the natural history of diabetes mellitus (DM) or mechanisms contributing to statin effects on DM among this population. ⋯ National Heart, Lung, and Blood Institute of the National Institutes of Health.
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Randomized Controlled Trial
In symptomatic knee OA, adding oral methotrexate to usual analgesia reduced pain at 6 mo.
Kingsbury SR, Tharmanathan P, Keding A, et al. Pain reduction with oral methotrexate in knee osteoarthritis: a randomized, placebo-controlled clinical trial. Ann Intern Med. 2024;177:1145-1156. 39074374.
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Randomized Controlled Trial Multicenter Study
Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial.
Primary care encounters are common among patients at risk for suicide. ⋯ National Institute of Mental Health.