Annals of surgery
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To explore the hypothesis that decreased arginine availability by myeloid-derived suppressor cells (MDSCs) is a cause of T-cell dysfunction after physical injury (PI). ⋯ Arginine availability is decreased after PI coinciding with an induction of MDSC expressing arginase 1. Decreased arginine may inhibit T-cell function and increase susceptibility to infection after injury.
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Review Meta Analysis
Preoperative smoking status and postoperative complications: a systematic review and meta-analysis.
To systematically review and summarize the evidence of an association between preoperative smoking status and postoperative complications elaborated on complication type. ⋯ Preoperative smoking was found to be associated with an increased risk of the following postoperative complications: general morbidity, wound complications, general infections, pulmonary complications, neurological complications, and admission to the intensive care unit.
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Meta Analysis Comparative Study
Comparison of treatment effect estimates from prospective nonrandomized studies with propensity score analysis and randomized controlled trials of surgical procedures.
We aimed to compare treatment effect estimates from NRSs with PS analysis and RCTs of surgery. ⋯ There was no statistically significant difference in treatment effect between NRSs with PS analysis and RCTs. Prospective NRSs with suitable and careful PS analysis can be relied upon as evidence when RCTs are not possible.