Health technology assessment : HTA
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Health Technol Assess · Apr 2019
Randomized Controlled Trial Clinical TrialTherapist telephone-delivered CBT and web-based CBT compared with treatment as usual in refractory irritable bowel syndrome: the ACTIB three-arm RCT.
Irritable bowel syndrome (IBS) affects 10-22% of people in the UK. Abdominal pain, bloating and altered bowel habits affect quality of life and can lead to time off work. Current treatment relies on a positive diagnosis, reassurance, lifestyle advice and drug therapies, but many people suffer ongoing symptoms. Cognitive-behavioural therapy (CBT) is recommended in guidelines for patients with ongoing symptoms but its availability is limited. ⋯ Longer-term follow-up and research to translate these findings into usual clinical practice is needed.
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Health Technol Assess · Apr 2019
Randomized Controlled Trial Multicenter Study Clinical TrialA group memory rehabilitation programme for people with traumatic brain injuries: the ReMemBrIn RCT.
People with traumatic brain injuries (TBIs) commonly report memory impairments. These are persistent, debilitating and reduce quality of life, but patients do not routinely receive memory rehabilitation after discharge from hospital. ⋯ The group memory rehabilitation delivered in this trial is very unlikely to lead to clinical benefits or to be a cost-effective treatment for people with TBI in the community. Future studies should examine the selection of participants who may benefit most from memory rehabilitation.
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Health Technol Assess · Apr 2019
Treatment of first-time traumatic anterior shoulder dislocation: the UK TASH-D cohort study.
Shoulder dislocations are the most common joint dislocations seen in emergency departments. Most traumatic cases are anterior and cause recurrent dislocations. Management options include surgical and conservative treatments. There is a lack of evidence about which method is most effective after the first traumatic anterior shoulder dislocation (TASD). ⋯ The National Institute for Health Research Health Technology Assessment programme.
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Health Technol Assess · Apr 2019
Randomized Controlled Trial Clinical TrialAdalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT.
Children with juvenile idiopathic arthritis (JIA) are at risk of uveitis. The role of adalimumab (Humira®; AbbVie Inc., Ludwigshafen, Germany) in the management of uveitis in children needs to be determined. ⋯ A clinical trial is required to define the most effective time to stop therapy. Prognostic biomarkers of early and complete response should also be identified.