British journal of anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly.
We compared the effects of remifentanil and alfentanil on arterial pressure and heart rate at induction of anaesthesia and tracheal intubation in 40 ASA I-III patients aged greater than 65 yr, in a randomized double-blind study. ⋯ Remifentanil and alfentanil similarly attenuate the pressor response to laryngoscopy and intubation, but the incidence of hypotension confirms that both drugs should be used with caution in elderly patients.
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Randomized Controlled Trial Comparative Study Clinical Trial
Remifentanil by patient-controlled analgesia compared with intramuscular meperidine for pain relief in labour.
The pharmacokinetics of remifentanil suggests that it may be suitable for analgesia during labour. ⋯ In this pilot study, remifentanil by PCA gave better pain relief to mothers in labour than intramuscular meperidine. However, remifentanil is a potent respiratory depressant and adequate continuous monitoring is necessary.
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Randomized Controlled Trial Clinical Trial
Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section.
In a prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of adding meperidine 10 mg to intrathecal bupivacaine on the duration of early postoperative analgesia in 40 patients having elective Caesarean section under spinal anaesthesia. ⋯ Addition of meperidine 10 mg to intrathecal bupivacaine for Caesarean section is associated with prolonged postoperative analgesia but with greater intraoperative nausea and vomiting.