British journal of anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Plasma substitution effects of a new hydroxyethyl starch HES 130/0.4 compared with HES 200/0.5 during and after extended acute normovolaemic haemodilution.
The volume expansion effect of a recently introduced hydroxyethyl starch, HES 130/0.4, was compared with the commonly used HES 200/0.5 after rapid infusion of a single large dose (up to 2 litres) administered during acute normovolaemic haemodilution (ANH). ⋯ This study demonstrates a good immediate and medium-term plasma volume substitution effect of HES 130 compared with HES 200. HES 130 could represent a suitable synthetic colloid for plasma volume substitution during extensive ANH.
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Clinical Trial
Effects of magnesium sulphate on cerebral haemodynamics in healthy volunteers: a transcranial Doppler study.
Magnesium is increasingly being considered as a neuroprotective agent. We aimed to study its effects on middle cerebral artery blood flow velocity (V(mca)), cerebral autoregulation and cerebral vascular reactivity to carbon dioxide (CRCO(2)) in healthy volunteers. ⋯ Infusion of magnesium sulphate, in a dose that doubles its concentration in plasma, does not affect V(mca), strength of autoregulation or CRCO(2) in healthy volunteers. However, it can be associated with nausea and hypotension.
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Randomized Controlled Trial Clinical Trial
Effect of intravenous alizapride on spinal morphine-induced pruritus.
This double-blind study was undertaken to determine whether alizapride inhibits spinal morphine-induced pruritus. ⋯ Alizapride reduced the severity of morphine-induced pruritus.
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Clinical Trial Controlled Clinical Trial
Dose-related effect of sevoflurane sedation on higher control of eye movements and decision making.
Saccadic latency may provide an objective method to assess sedative doses of anaesthetic on cortical oculomotor mechanisms and decision making. ⋯ Measurements of this kind could potentially provide estimates of cortical effects of sevoflurane sedation, and give a clinically useful measure of cognitive fitness.