British journal of anaesthesia
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About 98% of plasma propofol is bound to albumin. We investigated if severe hypoalbuminaemia may affect the accuracy of a target-controlled infusion (TCI) device, the Diprifusor, during sedation in critically ill patients. ⋯ Hypoalbuminaemia does not affect the accuracy of Diprifusor during sedation with propofol in critically ill patients.
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The purpose of this study is to test precision and systematic bias of a target controlled infusion (TCI) of propofol in human volunteers at two sedative concentrations. ⋯ This finding helps to explain differences in responses to propofol sedation; pharmacokinetic variability appears to be an important factor.
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Randomized Controlled Trial Clinical Trial
Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery.
This placebo-controlled, double-blind study was designed to assess the effects of magnesium sulphate and clonidine on peroperative haemodynamics, propofol consumption and postoperative recovery. ⋯ Clonidine caused bradycardia and hypotension and magnesium sulphate caused delayed recovery, but can be used as adjuvant agents with careful management.