British journal of anaesthesia
The most recent articles from:
Br J Anaesth
2006
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Randomized Controlled Trial Comparative Study
Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section.
Comparative studies of ephedrine and phenylephrine in prevention of hypotension after spinal anaesthesia for Caesarean section have lacked a consensus on dose equivalence. The aim of this study was to determine the minimum vasopressor dose for each of these drugs to calculate the dose ratio for clinical equivalence in the prevention of hypotension. ⋯ This study demonstrates a potency ratio of 81.2 (95% CI 73.0-89.7) for equivalence between phenylephrine and ephedrine in prevention of hypotension after spinal anaesthesia for Caesarean section.