British journal of anaesthesia
-
Review Meta Analysis
Benefits and risks of epidural analgesia in cardiac surgery†.
Epidural analgesia reduces all-cause mortality after cardiac surgery, at the cost of a 1 in 3,500 risk of epidural hematoma.
pearl -
Randomized Controlled Trial
A Randomised feasibility study to assess a novel strategy to rationalise fluid in patients after cardiac surgery.
After cardiac surgery, patients receive large amounts of fluid in the Intensive Care Unit (ICU). We plan to conduct a multi-centre randomised controlled trial, of a conservative fluid regime, in patients after cardiac surgery, and have reported results of a feasibility study that evaluated efficacy and safety of the proposed regime. ⋯ Australia New Zealand Clinical Trials Registry www.anzctr.org.au (ACTRN12612000754842).
-
Randomized Controlled Trial
Effect of propofol on the medial temporal lobe emotional memory system: a functional magnetic resonance imaging study in human subjects.
Subclinical doses of propofol produce anterograde amnesia, characterized by an early failure of memory consolidation. It is unknown how propofol affects the amygdala-dependent emotional memory system, which modulates consolidation in the hippocampus in response to emotional arousal and neurohumoral stress. We present an event-related functional magnetic resonance imaging study of the effects of propofol on the emotional memory system in human subjects. ⋯ NCT00504894.
-
Randomized Controlled Trial
Effect of subanaesthetic ketamine on plasma and saliva cortisol secretion.
The commonality between chronic conditions that are treated with low-dose ketamine, such as specific chronic pain conditions, depression, and post-traumatic stress disorder, can be found in relation to the stress system, particularly the hypothalamus-pituitary-adrenal axis. In this study we assess the effect of ketamine on the stress system by measuring plasma and saliva cortisol production during and following exposure to low-dose ketamine. ⋯ This study was registered in the Dutch Trial Register under number NTR2717 at www.trialregister.nl.