British journal of anaesthesia
-
Review Meta Analysis
Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis.
Dexmedetomidine reduces perioperative stress and inflammation, while supporting surgical patients’ immune function.
pearl -
Review Practice Guideline
2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery.
-
Review
Dopaminergic neurotransmission and genetic variation in chronification of post-surgical pain.
Chronic post-surgical pain (CPSP) is a debilitating condition affecting 10-50% of surgical patients. The current treatment strategy for CPSP is not optimal, and the identification of genetic variation in surgical patients might help to improve prediction and treatment of CPSP. The neurotransmitter dopamine (DA) has been associated with several chronic pain disorders. ⋯ Because of this modulatory role, DA is an excellent pharmacological target in the treatment of pain. Pharmacotherapy focused on DA neurotransmission has potential in both prevention (via D1-like receptors) and treatment (via D2-like receptors and DA reuptake inhibitors) of CPSP. The development of prediction models including genetic risk factors is necessary to better identify patients at risk.