British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Pre-emptive effect of epidural sufentanil in abdominal hysterectomy.
Experimental studies suggest pre-emptive administration of analgesics is effective but clinical evidence is less convincing. ⋯ We conclude that pre-emptive analgesia with epidural sufentanil was associated with a short-term sufentanil-sparing effect, and could have reduced stress hormone responses and wound sensitization after abdominal hysterectomy.
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Randomized Controlled Trial Clinical Trial
Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children.
In children, sevoflurane anaesthesia is associated with postanaesthetic agitation, which is treated mainly with opioids. We compared the effectiveness of epidural and i.v. clonidine in the prevention of this postanaesthetic agitation. ⋯ Clonidine 3 micrograms kg-1 prevented agitation after sevoflurane anaesthesia, independently of the route of administration. The effect of clonidine appears to be dose-dependent, as an epidural dose of 1 microgram kg-1 failed to reduce it.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of the effects of sevoflurane and propofol on cortical somatosensory evoked potentials.
Propofol (P) and sevoflurane (S) are potential anaesthetic agents if electrophysiological monitoring is required during spinal surgery. They allow rapid recovery and do not depress cortical somatosensory evoked potentials (SSEP) as much as other agents. The effects of these agents on SSEP have not been compared before. ⋯ Sevoflurane affected SSEP recordings in a dose-dependent fashion. Propofol had a minimal effect on SSEP recordings.
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Sevoflurane protects the heart against reperfusion injury even after cardioplegic arrest. This protection may depend on the cardioplegic solution. Therefore, we investigated the effect of sevoflurane on myocardial reperfusion injury after cardioplegic arrest with University of Wisconsin solution (UW), Bretschneider's cardioplegia (HTK), and St Thomas' Hospital solution (STH). ⋯ We conclude, that the protection against reperfusion injury offered by sevoflurane is independent of the three cardioplegic solutions used.
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Randomized Controlled Trial Clinical Trial
Effect of timing of morphine administration during remifentanil-based anaesthesia on early recovery from anaesthesia and postoperative pain.
Since the time to peak analgesic effect of intravenous morphine can be longer than 40-60 min in volunteers, the goal of this study was to evaluate the effect of the timing of intraoperative morphine administration on early postoperative pain. ⋯ The timing of intraoperative morphine administration did not affect the early recovery from anaesthesia. However, the reduction in the number of patients requiring morphine in the PACU when morphine had been given more than 40 min before the end of surgery supports this practice, rather than administration closer to the end of surgery.