British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Extradural bupivacaine with sufentanil for vaginal delivery. A double-blind trial.
The combination of sufentanil with bupivacaine plus adrenaline given extradurally for pain relief during labour was studied in a double-blind trial. One hundred and twenty patients were randomly divided into three groups and received a 10-ml extradural injection of sufentanil 15 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, sufentanil 7.5 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, or bupivacaine 12.5 mg + adrenaline 12.5 micrograms (control group). A second injection, which was given upon request, was identical to the first. ⋯ Moreover, the quality of analgesia was better and less bupivacaine was required, resulting in less motor blockade at delivery. There were no differences between the three groups in regard to Apgar scores. The only side effect of sufentanil was pruritus.
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Randomized Controlled Trial Comparative Study Clinical Trial
Intrathecal sufentanil as a supplement to subarachnoid anaesthesia with lignocaine.
The combination of low-dose sufentanil with lignocaine for subarachnoid anaesthesia was studied in a double-blind comparative trial in 40 urological patients. Patients were allocated randomly to two groups and received 5% heavy lignocaine 1.5 ml together with either 1.5 ml of sufentanil 5 micrograms ml-1, or physiological saline 1.5 ml. ⋯ There was no significant difference in the number of patients requiring supplementary analgesics. Side-effects were similar in both groups.
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Gas exchange was modelled by a Fortran program. Arterial blood-gas tensions have higher resolution than inert gas retentions in terms of distinguishing a single VA/Q compartment from a progressively broadening lognormal distribution. ⋯ The way in which the arterial blood-gas tensions vary with the variables of two and three-compartment distributions is described. Two- and three-compartment VA/Q distributions are derivable from either arterial blood-gas tensions or inert gas retentions.
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Comparative Study
Neuroleptic malignant syndrome and malignant hyperthermia. In vitro comparison with halothane and caffeine contracture tests.
The in vitro halothane and caffeine contracture tests have been performed on muscle tissue from six survivors of the neuroleptic malignant syndrome. The results, which are expressed in accordance with the criteria of the European MH Group, defined five of the subjects as MHN and one patient as MHE. It is concluded that there is no common pathophysiological link between the neuroleptic malignant syndrome and malignant hyperthermia.