International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled Trial Multicenter Study Controlled Clinical TrialGender, age, disease severity, body mass index, and diabetes may not affect response to subcutaneous tanezumab in patients with osteoarthritis after 16 weeks of treatment. A subgroup analysis of placebo-controlled trials.
To assess the impact of pre-specified patient characteristics on efficacy and safety of subcutaneous tanezumab in patients with osteoarthritis (OA). ⋯ Efficacy and safety/tolerability of tanezumab may not be meaningfully impacted by gender, age, BMI, diabetes status, baseline pain severity or KL grade in the index joint. Conclusions are limited by low patient number in some subgroups. Clinicaltrials.gov: NCT02697773, NCT02709486, NCT01089725.
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialThe effect of low dose ketamine on postoperative quality of recovery in patients undergoing breast cancer surgery: a randomized, placebo-controlled trial.
Low-dose ketamine has been proved to reduce opioid consumption, prevent depressant action and improve postoperative analgesia. Women undergoing mastectomy experience may not only have persistent postoperative pain syndromes but also emotional problems. However, the effect of intraoperative infusion of low-dose ketamine on postoperative quality of recovery among these patients has not yet been fully studied. ⋯ Intraoperative low-dose ketamine infusion did not improve the overall quality of recovery on POD 1 in patients undergoing breast cancer surgery.
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialCan zirconia crowns be the first restorative choice after endodontic treatment of primary teeth?
Early loss of primary teeth due to caries can cause temporary or permanent problems, such as occlusion disorders, aesthetic problems, nutritional problems, abnormal habits, and speech disorders. Although the development of restorative materials has led to significant improvements, failures are still frequent. The purpose of this study was to evaluate the success rates of zirconia crowns compared to other crowns for the restoration of endodontically treated teeth with excessive loss of material. ⋯ The clinical outcomes of ZCs were comparable to those of the other crowns. ZCs could be a choice for aesthetic purposes, with the disadvantage of a higher cost.
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialEffectiveness of hierarchical, diversified soft skills training in clinical nursing training.
To explore the application effects of hierarchical, diversified soft skills training in clinical nursing training. ⋯ Hierarchical, diversified soft skills training in clinical nursing training programme obtained better outcomes in the core competence, knowledge, operation skills and clinical competence of nursing staff, and promoted the satisfaction of doctors and patients, which can be utilised for clinical practice.
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialThe effect of vitamin D and exercise on balance and fall risk in postmenopausal women : a randomized controlled study.
To evaluate the effects of vitamin D and exercise on balance, fall risk and quality of life (QoL) in postmenopausal women. ⋯ Vitamin D replacement therapy has positive effects on balance and QoL. Core strengthening and balance exercises are essential for better balance and fall prevention in postmenopausal women. Any superior effect of vitamin D or exercise on each other was not determined.