European journal of pain : EJP
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Randomized Controlled Trial
Tropisetron alleviate early post-operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: A randomized, parallel-group, factorial study.
Studies have suggested that 5-hydroxytryptamine-3A (5-HT-3A) receptor antagonists may have analgesic effects. This randomized, double-blind, placebo-controlled, factorial study tested the hypothesis that 5-HT-3A receptor antagonist tropisetron attenuates post-operative pain in women receiving either sevoflurane or propofol based anaesthesia. ⋯ A single-dose intravenous administration of tropisetron after anaesthesia induction is associated with statistically significant decreased early post-operative pain in patients undergoing gynaecological laparoscopies under sevoflurane based general anaesthesia.
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Randomized Controlled Trial
Prevalence of cold-related musculoskeletal pain according to self-reported threshold temperature among the Finnish adult population.
Exposure to cold reportedly increases musculoskeletal pains. We assessed the prevalence of such pain and self-reported threshold temperature (TT) at which the pain emerges. ⋯ People suffering from musculoskeletal disorders and those living in the warmer areas of Finland need special advice to protect themselves against the cold. Our study provides preliminary information to support such advice.