American journal of veterinary research
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Randomized Controlled Trial Clinical Trial
Effect of medetomidine administration on bispectral index measurements in dogs during anesthesia with isoflurane.
To determine the relationship between bispectral index (BIS) and minimum alveolar concentration (MAC) multiples of isoflurane after IM injection of medetomidine or saline (0.9% NaCl) solution in anesthetized dogs. ⋯ BIS monitoring in dogs anesthetized with isoflurane has a predictive value in regard to degree of CNS depression. During isoflurane anesthesia, our results support a MAC-reducing effect of medetomidine.