Minerva anestesiologica
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Minerva anestesiologica · Jun 2014
A pharmacokinetic study of 48-hour sevoflurane inhalation using a disposable delivery system (AnaConDa©) in ICU patients.
Little is known regarding sevoflurane kinetics and toxicity during long-term sedation of intensive care unit (ICU) patients using the AnaConDa® system. The objective of the present study was to establish a pharmacokinetic description of 48-h sevoflurane administration, and to estimate plasma concentrations of metabolites. ⋯ Following 48 hours of sedation using sevoflurane inhalation administered using an AnaConDa® delivery device, sevoflurane washout was rapid. Plasma fluoride levels accumulated over the study period without apparent nephrotoxicity.
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Minerva anestesiologica · Jun 2014
Randomized Controlled TrialTotal Intra Venous Anesthesia with Superficial Cervical Block or Morphine Transition in Patients Undergoing Carotid Endarterectomy.
The aim of this study was compare the Aldrete score at 5 minutes of two groups of patients undergoing carotid endarterectomy with intravenous anesthesia, receiving either anesthetic superficial cervical plexus block or intravenous morphine as transition analgesia. ⋯ This study demonstrates shorter time to extubation and better emergence from anesthesia when total intravenous anesthesia is associated with superficial cervical block than with morphine as transition analgesia.