Minerva anestesiologica
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Minerva anestesiologica · Apr 2020
Presurgical cognitive impairment is associated with postoperative delirium and postoperative cognitive dysfunction.
Presurgical cognitive impairment (PreCI) is frequently seen in older age, but the influence on postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) remains unclear. The present study sought to determine the association between PreCI, POD and POCD with special focus to different PreCI domains. ⋯ Patients ≥ 60 years with PreCI were more likely to develop POD and POCD, respectively. The odds for POCD were highest in patients with PreCI whom also suffered from POD. Amnestic rather than non-amnestic PreCI might play a key role in the development of POD and POCD. These results warrant further pathophysiological investigations and demand preventive strategies.
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Minerva anestesiologica · Apr 2020
Methylene blue and the NO/cGMP pathway in solid organs transplants.
The nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway has a significative influence in hemodynamic changes that occur in transplants. Classically, the ischemia-reperfusion syndrome (IRS) is characterized by hypotension and low vascular resistance, when cGMP and nitric oxide (NO) are increased, contributing to oxidative stress, within an inflammatory context. ⋯ This review aims to study the NO/cGMP pathway in solid organ transplants. Finally, we inquire whether physicians do not underestimate the NO/cGMP pathway.
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Minerva anestesiologica · Apr 2020
Dextrose administration may reduce the incidence of postoperative nausea and vomiting after laporoscopic cholecystectomy: a double blind randomized controlled trial.
Pre-operative infusion of 5mL/kg of 5% dextrose before laparoscopic cholecystectomy reduces post-operative nausea & vomiting by ~30%.
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