Minerva anestesiologica
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Minerva anestesiologica · Apr 2022
Multicenter StudyDoes the definition of fluid responsiveness affect passive leg raising reliability? A methodological ancillary analysis from a multicentric study.
Fluid challenge (FC) is often adopted as gold standard used to assess the reliability of passive leg raising (PLR) in predicting fluid responsiveness in the intensive care unit (ICU). This study aimed to address the impact of the different definitions and timings used to assess FC response on PLR reliability. ⋯ The reliability of the PLR test to predict fluid responsiveness depends on the definition of FC adopted. The timing of FC outcome assessment affected the overall fluid responsiveness.
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Minerva anestesiologica · Apr 2022
Multicenter StudyEarly procalcitonin to predict mortality in critically ill COVID-19 patients: a multicentric cohort study.
High levels of procalcitonin (PCT) have been associated with a higher risk of mortality in COVID-19 patients. We explored the prognostic role of early PCT assessment in critically ill COVID-19 patients and whether PCT predictive performance would be influenced by immunosuppression. ⋯ PCT values are not independent predictors of ICU mortality in COVID-19 patients. Acute immunosuppression significantly reduced PCT values, although not influencing its predictive value.