World Neurosurg
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The causal relationship between mitochondrial DNA copy number (mtDNA-CN) and intervertebral disc degeneration (IVDD) remains unclear. The study aimed to investigate the causal relationship between mtDNA-CN and IVDD using Mendelian randomization analyses. ⋯ The study revealed that there is no causal relationship of mtDNA-CN on the risk of IVDD, nor does IVDD have a significant causal effect on mtDNA-CN. Although the study did not find a significant causal relationship, it provides valuable insights into the complex interplay between genetic factors and IVDD. Further research is needed to explore to better understand the underlying mechanisms of this condition.
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Uni-portal Bi-channel & Dual-media Spinal Endoscopy system (UBD) is an original and valuable endoscopic system. The purpose of this technical note is to describe a single-centre case series of elderly patients with Thoraco-lumbar kyphosis with osteoporosis treated with the assistance of UBD system. ⋯ This study suggests that UBD system assisting for elderly patients with rigid TLK with osteoporosis is a safe and effective approach.
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The mainstream approach for preventing cerebrovascular events in hemorrhagic or ischemic moyamoya disease (MMD) is surgical revascularization, and the indications for endovascular treatment (EVT) for MMD are limited. This systematic review aimed to evaluate the outcomes and complications associated with EVT in patients with MMD. ⋯ For the patients with MMD, EVT of distal aneurysms would likely be unsuccessful because of the access difficulties. Furthermore, EVT for intracranial arterial stenosis often results in unsatisfactory treatment and has limited indications owing to the risk of complications.