Ann Acad Med Singap
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Ann Acad Med Singap · Feb 2021
ReviewMetformin use in patients with type 2 diabetes mellitus and chronic kidney disease: An evidence-based review.
Practice guidelines advise caution on the use of metformin in patients with type 2 diabetes mellitus with chronic kidney disease (CKD). This review aims to examine the evidence for the benefits and risks of metformin use in patients with T2DM and CKD. ⋯ Existing recommendations to restrict metformin use in diabetes patients with CKD need to be reviewed in light of emerging evidence supporting its overall benefits in these patients.