Dtsch Arztebl Int
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The systemic treatment of metastatic melanoma has improved considerably with the introduction of new, targeted substances and immune checkpoint inhibitors. This article presents treatment options for advanced inoperable melanoma and in the setting of adjuvant treatment after complete metastasectomy. ⋯ High-quality studies show that the new substances are clinically effective in the palliative and adjuvant treatment of melanoma.