Niger J Clin Pract
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Piperlongumine (PL) is an alkaloid derived from the edible pepper (Piper longum L) and it has been described to have various biologic activities including anticancer effects. Our aim in this study was to assess the cytotoxic role of PL on a cervical cancer cell line (HeLa) and to evaluate the effects of PL/doxorubicin and PL/paclitaxel combination therapies on apoptotic cancer cell death. ⋯ We conclude that the PL inhibits cancer cell growth by inducing apoptosis and has a potential anticancer activity in cervical cancer, especially when combined with doxorubicin and paclitaxel.
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Genital infections are one of the most common reasons for a hospital visit in the scope of reproductive health problems. The information-motivation-behavioral skills (IMB), therefore, is an appropriate model to provide women with accurate genital hygiene behaviors and develop effective sexual and reproductive health training programs. ⋯ Based on these findings, it was concluded that the genital infection awareness training provided to women based on the IMB model, improved knowledge and acted as a positive reinforcer for the hygiene behaviors of the women.
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The aim of this in-vitro study was to investigate the effects of frequently consumed beverages on the color stability and microhardness of various restorative materials. ⋯ The color and hardness of restorative materials can be negatively affected by consumed beverages. Nanohybrid composite resins are resistant to external coloration and hardness change.
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Congenital agenesis of lateral incisor is one of the most prevalent dental anomalies and is commonly treated by correcting the axes of maxillary central and canine teeth deviated toward the deficient area orthodontically, replacing the missing maxillary lateral incisor with dental implants and prosthetic restorations. Conducting treatment in interdisciplinary manner is the main criterion for the successful outcome. ⋯ As encountered in this case, bone resorption may occur if there is very limited bone-width or if there is a past of orthodontic treatment. In contemporary dentistry, this biological complication can be treated with the aid of a mixture including bovine bone graft material and advanced platelet-rich fibrin.
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Diabetes mellitus is one of the most widely spread systemic diseases worldwide. It is characterized by hyperglycemic status with major multiorgan impact. With regard to the oral cavity, the relationship between diabetes mellitus and periodontal disease is well-known, although other dental diseases have been neglected. ⋯ The results obtained show a higher incidence of apical periodontal infections, regardless of the compensation level of type 2 diabetes mellitus.