Singap Med J
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Randomized Controlled Trial
Melatonin premedication does not enhance induction of anaesthesia with sevoflurane as assessed by bispectral index monitoring.
Exogenous melatonin has sedating and hypnotic actions. The present prospective double-blind randomised study investigated the effect of melatonin premedication on the induction of anaesthesia with sevoflurane. ⋯ Melatonin premedication under the present study design failed to enhance the induction of anaesthesia with sevoflurane.
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Randomized Controlled Trial Comparative Study
Comparison of effects of anaesthesia with desflurane and enflurane on liver function.
Although most general anaesthesia procedures are performed without any complications, volatile agents may have adverse effects on various living systems. This study aimed to compare the effects of desflurane and enflurane on liver function. ⋯ Subclinical hepatic injury after anaesthesia continues to be an issue of interest, particularly with the development of new, more sensitive methods of measuring GST levels. The increase in GST concentration after anaesthesia is thought to be a result of reduced hepatic blood flow. This study has shown that desflurane has fewer effects than enflurane on liver function tests in lengthy operations of up to 330 minutes.