Terapevt Arkh
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Randomized Controlled Trial Comparative Study Clinical Trial
[Treatment and prevention of cognitive dysfunction in patients with arterial hypertension and atherosclerosis: results of a randomized double-blind placebo-controlled trial of cerebrolysin].
To assess therapeutic and prophylactic effect of large-dose cerebrolysin (15 ml/day for 28 days) in hypertensive and atherosclerotic patients with cognitive disorders. ⋯ A course of 28-day annual treatment with cerebrolysin (15 ml/day) of patients with mild defects of cognitive functions stabilizes the process, leads to regression of cognitive disorders predicting vascular dementia.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Comparative study of spirapril (quadropril) and amlodipine efficacy. Results of randomized trial in patients with mild to moderate arterial hypertension].
To compare in the non-blind randomised parallel study the efficiency of quadropril and amlodipine in the treatment of mild to moderate arterial hypertension. ⋯ Both quadropril and amlodipine demonstrated a comparable antihypertensive effect although in 11 of 40 patients in the amlodipine group a dose increase was necessary and tolerability of quadropril was better.
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Randomized Controlled Trial Clinical Trial
[Plasma myoglobin and continuous hemofiltration in patients with rhabdomyolysis and acute kidney failure].
Plasma and filtrate levels of myoglobin, specific antibodies and immune complexes were measured by radioimmunoassay or enzyme immunoassay in patients with rhabdomyolysis and acute renal failure on continuous hemofiltration (CHF). 14 of them had crush syndrome, 7 had other forms of rhabdomyolysis. 11 patients died (52%) because of the underlying disease or its complications. Rhabdomyolysis was associated with marked and long-lasting myoglobinemia. ⋯ CHF provided elimination of large amounts of myoglobin with filtrate. In rhabdomyolysis in all cases there appeared specific antibodies and circulating immune complexes.
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Randomized Controlled Trial Comparative Study Clinical Trial
[The outpatient treatment possibilities for patients with exacerbated peptic ulcer].
The efficacy of hospital and ambulatory treatment of patients with peptic ulcer exacerbation was compared. 209 patients were treated in the hospital and 116 on an ambulatory basis. No appreciable differences were found in the times of the removal of the painful syndrome or gastroduodenal ulcer healing. At the same time early relapses were recorded in 26.4% of the inpatients and in 14.9% of the outpatients. Indications for the treatment of outpatients with gastroduodenal ulcers were developed: rare relapses, lack of complications, moderate painful syndrome, small ulcer dimensions, a possibility of arranging good treatment and control over ulcer healing, favourable living conditions, and being in a positive mood for outpatient treatment.
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Randomized Controlled Trial Comparative Study Clinical Trial
[The efficacy of bifidum-containing preparations in enterogenous reactive arthritis].
Analysis is made of the intestinal microflora in 43 patients suffering from reactive arthritides (ReA) that developed after intestinal infection. The overwhelming majority of the patients manifested a decrease of the level of the bifidoflora. ⋯ Bifidumbacterine was found to produce a significant beneficial effect on the course of ReA and to cause no serious side effects. According to the preliminary data, the efficacy of bifidumbacterin exceeded that of the known basic drug salazopyridazine, thus making it possible to apply the bifidum-containing drugs as basic agents in the treatment of ReA.