Respiratory care
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Review Meta Analysis Comparative Study
Thrombolysis Versus Anticoagulation for the Initial Treatment of Moderate Pulmonary Embolism: A Meta-Analysis of Randomized Controlled Trials.
Randomized trials and meta-analyses have reached conflicting conclusions regarding the risk benefit ratio of thrombolytic therapy or anticoagulant therapy in patients with moderate pulmonary embolism. To investigate the effect of initial thrombolysis and anticoagulant therapy in patients with moderate pulmonary embolism, we performed an updated meta-analysis. ⋯ Both mortality and pulmonary embolism recurrence are decreased with thrombolysis compared with heparin treatment in patients with moderate pulmonary embolism. The risk of non-major bleeding is increased, but the risk of major bleeding is not.