Respiratory care
-
Improving [Formula: see text] and reducing CO2 rebreathing ([Formula: see text]) are the key means to improve the therapeutic efficacy of noninvasive ventilation (NIV). This study aimed to investigate the impact of interface design on [Formula: see text] and [Formula: see text] during NIV. ⋯ The design of the interface had a significant impact on [Formula: see text] and [Formula: see text] during NIV. [Formula: see text] and [Formula: see text] showed a significant positive correlation, although the effect size of correlation was moderate.
-
Review Meta Analysis
Neuromuscular Blocking Agents for ARDS: A Systematic Review and Meta-Analysis.
Studies evaluating neuromuscular blocking agents (NMBAs) in the management of ARDS have produced inconsistent results in terms of their effect on mortality. The purpose of this systematic review and meta-analysis was to evaluate differences in mortality comparing subjects with ARDS who received NMBA to those who received placebo or usual care. ⋯ In subjects with ARDS, early use of NMBAs improves oxygenation, reduces the incidence of ventilator-induced lung injury, and decreases 21-28-d mortality, but it does not improve 90-d mortality. NMBAs should be considered for select patients with moderate-to-severe ARDS for short durations.