Journal of the Medical Association of Thailand = Chotmaihet thangphaet
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Randomized Controlled Trial
Efficacy of a Single Intra-Articular Injection of 2% Sodium Hyaluronate Plus 0.5% Mannitol in Patients with Symptomatic Osteoarthritis of the Knee: A Preliminary Report.
Intra-articular injection of hyaluronic acid is widely used as a treatment for osteoarthritis of the knee. The recommended dosing regimens have generally ranged from 3 to 5 injections. ⋯ Symptomatic OA knee patients who received a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol had better outcomes over the 24-week follow-up period than control group patients who received no injection intervention.
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Multicenter Study Observational Study
Incidence and Risk Factors of Unplanned Extubation in Critically Ill Surgical Patients: The Multi-center Thai University-based Surgical Intensive Care Units Study (THAI-SICU Study).
Unplanned extubation (UE) is one of the most troubling events in critically ill patients who require endotracheal intubation and mechanical ventilation. The aims of this study are to determine the incidence and to identify the risk factors associated with UE in critically ill surgical patients. ⋯ The incidence of UE in critically ill surgical patients was 1.9%. Five independent risk factors for UE were: underlying congestive heart failure, emergency surgery, non-postoperative status, sedation usage, and delirium. Patients with UE had significantly longer ICU LOS than those with planned extubation.
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Multicenter Study Observational Study
Incidence of and Risk Factors for Acute Respiratory Distress Syndrome in Patients Admitted to Surgical Intensive Care Units: The Multicenter Thai University- Based Surgical Intensive Care Unit (THAI-SICU) Study.
The incidence and outcomes of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are unclear. We evaluated the cumulative incidence of, risk factors for, and outcomes of ALI/ARDS in surgical ICUs (SICUs). ⋯ The incidence of ALI/ARDS in the THAI-SICU study was low, but the mortality rate was high. Higher severity scores and smoking were associated with ALI/ARDS.
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Multicenter Study Observational Study
Incidence, Outcomes and Risk Factors for Mortality of Symptomatic upper Gastrointestinal Hemorrhage in Surgical Critical Ill Patients (THAI SICU Study).
This multicenter university-based study reports the incidence, outcomes and defined risk factors for mortality of upper gastrointestinal hemorrhage (UGIH) patients in the surgical intensive care units (ICU) patients in Thailand. ⋯ The incidence of symptomatic UGIH in the THAI-SICU study was 1.18% and UGIH was associated with higher 28-day mortality rate and prolonged ICU length of stay. The risk factors for mortality were coagulopathy, renal failure, APACHE II score and vasopressor use.
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Multicenter Study Observational Study
Hazards and Intensive Care Unit Economic Burden of Cigarette Smoking on Critically Ill Surgical Patients: Analysis of the THAI-SICU Study.
Cigarette smoking is not only has detrimental effects on the respiratory system but also contributes to development of atherosclerosis and inflammatory vascular reactions. We hypothesized whether smoking is associated with increased risk of acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), sepsis, distant organ dysfunctions, and the increase of total cost of surgical intensive care unit (SICU) in critically ill surgical patients. ⋯ In critically ill surgical patients, we found dose-response association between smoking pack year and risk of ARDS. Compared to patients who had never smoked and former smokers, current smokers had significantly higher probability of ARDS, higher incidence of SIRS, AKI, and higher total SICU cost. Our findings demonstrated harm of cigarette smoking in critically ill surgical patients who admitted to SICU.