Journal of the Medical Association of Thailand = Chotmaihet thangphaet
The most recent articles from:
J Med Assoc Thai
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Meta Analysis Comparative Study
Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis.
Despite the scanty data, proton pump inhibitors (PPI) are widely used for stress-related mucosal disease (SRMD) prophylaxis. There were few studies using PPI for SRMD prophylaxis but the results were conflicting, most probably due to inadequate sample size. The present meta-analysis aimed to determine the efficacy of PPI, as compared to histamine-2 receptor antagonists (H2RA) in the prevention of SRMD in critically-ill patients. ⋯ The use of PPI for SRMD prophylaxis was associated with a significantly lower rate of clinically important bleeding than H2RA with similar rates of nosocomial pneumonia.