Biological psychiatry
The most recent articles from:
Biol. Psychiatry
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Biological psychiatry · Nov 2010
Multicenter StudyYKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease.
Disease-modifying therapies for Alzheimer's disease (AD) would be most effective during the preclinical stage (pathology present, cognition intact) before significant neuronal loss occurs. Therefore, biomarkers that detect AD pathology in its early stages and predict dementia onset and progression will be invaluable for patient care and efficient clinical trial design. ⋯ These data demonstrate that YKL-40, a putative indicator of neuroinflammation, is elevated in AD and, together with Aβ42, has potential prognostic utility as a biomarker for preclinical AD.