Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk
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Ross Fiziol Zh Im I M Sechenova · Oct 2014
Review[The problems of experimental investigation of spaceflight factors combined influence on animals organism functions].
The brief analytic review of exceedingly important, tough, but the insufficient investigated problem of experimental investigation of spaceflight factors (SF) combined influence on animal organism functions is the content of this paper. The basic limited factor for interplanetary spaceflights is ionizing radiation. Therefore, in the paper studies the matters of the effects of combined influence and the different nonradiation SF. ⋯ Besides of that, in the paper studies the matters of character of interaction and mutual modifications of the combined effects of different SF: hypodynamia, G force, vibration, hypoxia, hyperthermia. The effects of this factor may have additive, potentiative, synergic or antagonistic character. In studies of SF combined influence effects the accentuation of the key factor and organism system that is targeted for this factor influence is necessary.
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Ross Fiziol Zh Im I M Sechenova · Mar 2011
Review[Vasopressin: molecular mechanisms of antidiuretic effect].
Body water balance is regulated by vasopressin, and multiple studies now have revealed essential role of aquaporins in this process. This review summarizes recent advances related to molecular events underlying the short-term control of water permeability which occurs via vesicular trafficking of AQP2 to the cell apical membrane, and long-term control through changes in the gene expression and the abundance of AQP-2, -3 and -4. The action of vasopressin on water permeability is counterbalanced by several factors such as prostaglandin E2, bradykinin, dopamin, endotelin-1 and others. Changes in AQP-2 expression / trafficking are of particular importance in pathological conditions characterized by both diluting and concentration defect of renal function.
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Ross Fiziol Zh Im I M Sechenova · Oct 2009
Review[Complications of portal hypertension in the liver cirrhosis].
Hypertension in the portal vein system is a key pathophysiological factor of progressing cirrhosis of the liver. The radical technique of treatment of the liver decompensated cirrhosis involves transplantation of liver.