Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
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Tidsskr. Nor. Laegeforen. · Jun 2012
Randomized Controlled TrialProphylactic treatment of jellyfish stings--a randomised trial.
Contact with jellyfish can cause skin irritation and manifestations. We wanted to investigate the prophylactic effect of a sun cream containing an inhibitor against jellyfish stings. ⋯ Prophylactic treatment with jellyfish sting inhibitor reduces the risk of subjects developing symptoms after exposure to jellyfish tentacles.
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Tidsskr. Nor. Laegeforen. · Jan 2005
Randomized Controlled Trial Comparative Study Clinical Trial[Buprenorphine and methadone to opiate addicts--a randomized trial].
There are approximately 12,000 opioid dependants in Norway. Methadone-assisted treatment was approved in Norway in 1998, buprenorphine in 2000. This study compares the efficacy of methadone (n = 25) and buprenorphine (n = 25) assisted maintenance treatment in a group of long-term (> 10 years) opioid dependant. ⋯ After 180 days, patient retention was highest in the methadone group (85 % vs. 36 %, p < 0.0005). Days in treatment were 167 vs. 114 (95 % CI for difference 53 days (26-80), p < 0.001). Positive urine test rates for opiates (20 % vs 24 %, p < 0.01) and cannabis (33 % vs 45 %, p < 0.001) were lower in the methadone group which also had lower self-reported risk behaviour and psychological distress. However, only those on buprenorphine reported significant improvement in physical health. For older, long-term opioid dependants with significant co-morbidity and unsuccessful medication-free treatment, high-dose methadone maintenance appears to be the treatment of choice. However, in cases where methadone is poorly tolerated, buprenorphine therapy may be a good alternative.
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Tidsskr. Nor. Laegeforen. · Sep 2003
Randomized Controlled Trial Comparative Study Clinical Trial[Do short-term duration drugs for anaesthesia give postoperative advantages compared to traditional drugs?].
We wanted to compare totally intravenous anaesthesia with propofol and remifentanil to mixed anaesthesia with isoflurane and fentanyl in terms of postoperative pain, nausea, length of stay and costs. ⋯ The use of totally intravenous anaesthesia led to more nausea and more expenses than mixed anaesthesia in laparoscopic gynaecologic day-care surgery. No recommendations for either method can be made because of the non-randomized design.
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Tidsskr. Nor. Laegeforen. · Oct 1997
Randomized Controlled Trial Clinical Trial[Treatment chronic pain with amitriptyline. A double-blind dosage study with determination of serum levels].
The aim of this study was to find an optimal analgesic dose of amitriptyline, and at the same time examine whether a therapeutic window existed for this analgesic effect. 85 patients with chronic, non-malignant pain were included in a double-blind treatment regime with four doses of amitriptyline (10, 25, 50 or 100 mg). A blood sample was taken at steady state. ⋯ No therapeutic window was found, but one cannot exclude that it exists. Low-dose amitriptyline, as a non-addictive drug, is a good alternative in the treatment of chronic pain, independent of co-morbid depression.
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Tidsskr. Nor. Laegeforen. · Jun 1986
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial[Treatment of acute cystitis in women. Single-dose versus a 3-day and 10-day therapeutic regimen with with trimethoprim-sulfamethoxazole].