Yonsei medical journal
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Yonsei medical journal · Aug 2009
Randomized Controlled TrialThe effect of intensive oral hygiene care on gingivitis and periodontal destruction in type 2 diabetic patients.
This study aimed to investigate the effects of oral hygiene care by oral professionals on periodontal health in type 2 diabetes mellitus patients. ⋯ Intensive oral hygiene care can persistently improve oral inflammation status and could slow periodontal deterioration.
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Yonsei medical journal · Aug 2009
Polymorphism of a COLIA1 gene Sp1 binding site in Korean women with pelvic organ prolapse.
To evaluate the possible influence of G-->T substitution at the Sp1-binding site of the COLIA1 gene on the risk of pelvic organ prolapse (POP). ⋯ The polymorphism of the Sp1-binding site in the COLIA1 gene did not contribute to the development of POP in Korea.
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Yonsei medical journal · Aug 2009
Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients.
The pharmacokinetics of phenytoin is complicated by genetic and environmental differences. It is, therefore, important to monitor the serum concentrations in patients who receive phenytoin. Because most of the phenytoin in serum is bound to proteins, the level of serum albumin influences the amount of free phenytoin. ⋯ In hypoalbuminemic patients, the measurement of free phenytoin level is necessary to properly evaluate the phenytoin level than that calculated from total phenytoin level.
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Yonsei medical journal · Aug 2009
Case ReportsA case of extensive spinal cysticercosis involving the whole spinal canal in a patient with a history of cerebral cysticercosis.
Although cysticercosis is the most common parasitic disease affecting the central nervous system, spinal cysticercosis is rare. A rare form of spinal cysticercosis involving the whole spinal canal is presented. A 45-year-old Korean male had a history of intracranial cysticercosis and showed progressive paraparesis. ⋯ Three different levels (C1-2, T1-3, and T11-L1) required operation. Histopathological examination confirmed cysticercosis. The patient improved markedly after surgery.
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Yonsei medical journal · Aug 2009
Randomized Controlled Trial Retracted PublicationComparison of the effects of alendronate and alfacalcidol on hip bone mineral density and bone turnover in Japanese men having osteoporosis or osteopenia with clinical risk factors for fractures.
The comparative effects of alendronate and alfacalcidol on bone mineral density (BMD) and bone turnover have already been established in postmenopausal women with osteoporosis. An open-labeled prospective study was conducted to compare the treatment effects of alendronate and alfacalcidol on hip BMD and bone turnover in Japanese men with osteoporosis or osteopenia with clinical risk factors for fractures. ⋯ The present study confirmed that alendronate has better efficacy than alfacalcidol (active control) in increasing hip BMD and reducing bone turnover in Japanese men with osteoporosis or osteopenia with clinical risk factors for fractures.