Yonsei medical journal
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Yonsei medical journal · Sep 2014
Neck circumference and lowest oxygen saturation are independently associated with high coexistence of hypertension in obstructive sleep apnea.
Obstructive sleep apnea (OSA) is considered an independent risk factor for hypertension. However, it is still not clear which clinical factors are related with the presence of hypertension in OSA patients. We aimed to find different physical features and compare the sleep study results which are associated with the occurrence of hypertension in OSA patients. ⋯ Age and neck circumference should be considered as clinically significant features, and the lowest blood O₂ saturation during sleep should be emphasized in predicting the coexistence or development of hypertension in OSA patients.
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Yonsei medical journal · Sep 2014
Comparative StudySurgical outcomes of robotic radical hysterectomy using three robotic arms versus conventional multiport laparoscopy in patients with cervical cancer.
To compare surgical outcomes of robotic radical hysterectomy (RRH) using 3 robotic arms with those of conventional laparoscopy in patients with early cervical cancer. ⋯ Surgical outcomes of RRH and pelvic lymphadenectomy were comparable to that of laparoscopic approach, with significantly less blood loss and early postoperative complications.
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Yonsei medical journal · Sep 2014
Overexpression of mucin 13 due to promoter methylation promotes aggressive behavior in ovarian cancer cells.
Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are largely unknown. To address epigenetically-regulated gene products involved in ovarian cancer metastasis, we examined the mechanisms regulating mucin 13 (MUC13) expression and its influence on aggressive behaviors of ovarian malignancies. ⋯ We provide novel evidence for epigenetic regulation of MUC13 in ovarian cancer. We suggest that the DNA methylation status within the MUC13 promoter region may be a potential biomarker of aggressive behavior in ovarian cancer.
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Yonsei medical journal · Sep 2014
Clinical experience of weight loss surgery in morbidly obese Korean adolescents.
Comprehensive multidisciplinary weight management programs encompassing various conservative measures have shown only modest weight loss results in obese children and adolescents; therefore, bariatric surgery for this population has become a matter of discussion. This study aimed to present our experience with and outcomes for laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in morbidly obese Korean adolescents. ⋯ Bariatric surgery leads to significant short-term weight loss along with resolution of obesity-related comorbidities in obese children and adolescents.
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Yonsei medical journal · Sep 2014
The added value of double dose gadolinium enhanced 3D T2 fluid-attenuated inversion recovery for evaluating small brain metastases.
Single dose gadolinium (Gd) enhanced fluid-attenuated inversion recovery (FLAIR) is helpful for visualizing superficial parenchymal metastases. However, the usefulness of FLAIR with a higher dose of Gd is uncertain. The aim of our study was two-folds: first, to prove that the signal to noise ratio (SNR) of small brain metastases is higher than large brain metastases on double-dose (DD) enhanced FLAIR and, second, to explore the added value of DD Gd enhanced FLAIR in relation to T1 GRE for evaluating small brain metastases. ⋯ Small brain metastases showed higher signal intensity than large brain metastases on the DD Gd enhanced 3D T2 FLAIR images. DD Gd enhanced 3D T2 FLAIR imaging may have a complementary role to 3D T1 GRE for evaluating small brain metastases.