The lancet. Psychiatry
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The lancet. Psychiatry · Jun 2020
Randomized Controlled Trial Multicenter Study Comparative Study Pragmatic Clinical TrialCognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial.
Dissociative seizures are paroxysmal events resembling epilepsy or syncope with characteristic features that allow them to be distinguished from other medical conditions. We aimed to compare the effectiveness of cognitive behavioural therapy (CBT) plus standardised medical care with standardised medical care alone for the reduction of dissociative seizure frequency. ⋯ National Institute for Health Research, Health Technology Assessment programme.
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The lancet. Psychiatry · May 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialSmoking cessation for people with severe mental illness (SCIMITAR+): a pragmatic randomised controlled trial.
People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing to widening health inequalities. Smoking remains the largest modifiable risk factor for this health inequality, but people with severe mental illness have not historically engaged with smoking cessation services. We aimed to test the effectiveness of a combined behavioural and pharmacological smoking cessation intervention targeted specifically at people with severe mental illness. ⋯ National Institute for Health Research Health Technology Assessment Programme.
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The lancet. Psychiatry · Apr 2019
Randomized Controlled Trial Multicenter StudyClinical and cost-effectiveness of the Managing Agitation and Raising Quality of Life (MARQUE) intervention for agitation in people with dementia in care homes: a single-blind, cluster-randomised controlled trial.
Many people with dementia living in care homes have distressing and costly agitation symptoms. Interventions should be efficacious, scalable, and feasible. ⋯ UK Economic and Social Research Council and the National Institute of Health Research.
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The lancet. Psychiatry · Nov 2017
Randomized Controlled Trial Multicenter StudySubcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial.
Deep brain stimulation (DBS) of the subcallosal cingulate white matter has shown promise as an intervention for patients with chronic, unremitting depression. To test the safety and efficacy of DBS for treatment-resistant depression, a prospective, randomised, sham-controlled trial was conducted. ⋯ Abbott (previously St Jude Medical).
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The lancet. Psychiatry · Aug 2017
Randomized Controlled Trial Multicenter StudyDeutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial.
Tardive dyskinesia results from exposure to dopamine receptor antagonists, such as typical and atypical antipsychotics. If clinically appropriate, clinicians often manage this disorder by lowering the dose of, or discontinuing, the causative drug. There is a significant unmet need for a treatment option that does not disrupt treatment regimens for underlying psychiatric illnesses. We aimed to assess the efficacy, safety, and tolerability of fixed doses of deutetrabenazine-a novel vesicular monoamine transporter-2 inhibitor-in patients with tardive dyskinesia. ⋯ Teva Pharmaceutical Industries.