The lancet. Psychiatry
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The lancet. Psychiatry · Sep 2020
Randomized Controlled TrialEffectiveness of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal: a cluster randomised trial in Pakistan.
Maternal depression has a recurring course that can influence offspring outcomes. Evidence on how to treat maternal depression to improve longer-term maternal outcomes and reduce intergenerational transmission of psychopathology is scarce, particularly for task-shifted, low-intensity, and scalable psychosocial interventions. We evaluated the effects of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal. ⋯ National Institutes of Health.
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The lancet. Psychiatry · Jun 2020
Randomized Controlled Trial Multicenter Study Comparative Study Pragmatic Clinical TrialCognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial.
Dissociative seizures are paroxysmal events resembling epilepsy or syncope with characteristic features that allow them to be distinguished from other medical conditions. We aimed to compare the effectiveness of cognitive behavioural therapy (CBT) plus standardised medical care with standardised medical care alone for the reduction of dissociative seizure frequency. ⋯ National Institute for Health Research, Health Technology Assessment programme.
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The lancet. Psychiatry · May 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialSmoking cessation for people with severe mental illness (SCIMITAR+): a pragmatic randomised controlled trial.
People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing to widening health inequalities. Smoking remains the largest modifiable risk factor for this health inequality, but people with severe mental illness have not historically engaged with smoking cessation services. We aimed to test the effectiveness of a combined behavioural and pharmacological smoking cessation intervention targeted specifically at people with severe mental illness. ⋯ National Institute for Health Research Health Technology Assessment Programme.
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The lancet. Psychiatry · Apr 2019
Randomized Controlled Trial Multicenter StudyClinical and cost-effectiveness of the Managing Agitation and Raising Quality of Life (MARQUE) intervention for agitation in people with dementia in care homes: a single-blind, cluster-randomised controlled trial.
Many people with dementia living in care homes have distressing and costly agitation symptoms. Interventions should be efficacious, scalable, and feasible. ⋯ UK Economic and Social Research Council and the National Institute of Health Research.
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The lancet. Psychiatry · Feb 2019
Randomized Controlled TrialDelivering the Thinking Healthy Programme for perinatal depression through volunteer peers: a cluster randomised controlled trial in Pakistan.
The Thinking Healthy Programme (THP), which is endorsed by WHO, is an evidence-based intervention for perinatal depression. We adapted THP for delivery by volunteer peers (laywomen from the community) to address the human resource needs in bridging the treatment gap, and we aimed to assess its effectiveness and cost-effectiveness in Rawalpindi, Pakistan. ⋯ National Institute of Mental Health (USA).