The journal of pain : official journal of the American Pain Society
-
Randomized Controlled Trial
Research Article: The prediction of the analgesic placebo response is moderated by outward-focused attention: a sham, randomized clinical trial of chronic back pain patients.
The within-subject variability (WSV) of pain-intensity reports has gained attention as a predictor of the placebo response but has demonstrated mixed results. We hypothesized that participants' inward- and outward-directed attention will moderate WSV's prediction of the analgesic placebo response. In this sham randomized clinical trial (protocol number NCT05994118); placebo response was induced in chronic back-pain patients (n=113) through a saline injection plus verbal suggestion. ⋯ Better understanding of factors shaping the placebo response could further contribute to both clinical practice and clinical trials. PERSPECTIVE: The current study demonstrates that the prediction of the analgesic placebo response could be improved if relevant personal characteristics are included as moderators of the prediction. Better predictions of the placebo response could contribute to improve both clinical research and clinical care.