The lancet oncology
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The lancet oncology · Jun 2015
Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.
Mutations in PALB2 predispose to breast cancer, but the effect on prognosis of carrying a PALB2 mutation has not been ascertained. We aimed to estimate the odds ratio for breast cancer in women with an inherited mutation in PALB2 and 10-year survival after breast cancer in patients who carry a PALB2 mutation. ⋯ Polish National Science Centre.
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The lancet oncology · Jun 2015
A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies.
The likelihood of tumour recurrence after nephrectomy in localised clear cell renal cell carcinoma is well characterised by clinical and pathological parameters. However, these assessments can be improved and personalised by the addition of molecular characteristics of each patient's tumour. We aimed to develop and validate a prognostic multigene signature to improve prediction of recurrence risk in clear cell renal cell carcinoma. ⋯ Genomic Health Inc and Pfizer Inc.