The lancet oncology
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The lancet oncology · Jun 2023
Global funding for cancer research between 2016 and 2020: a content analysis of public and philanthropic investments.
Cancer is a leading cause of disease burden globally, with more than 19·3 million cases and 10 million deaths recorded in 2020. Research is crucial to understanding the determinants of cancer and the effects of interventions, and to improving outcomes. We aimed to analyse global patterns of public and philanthropic investment in cancer research. ⋯ None.
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The lancet oncology · Jun 2023
ReviewUtility of polygenic risk scores in UK cancer screening: a modelling analysis.
It is proposed that, through restriction to individuals delineated as high risk, polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer screening programmes and enable extension into new age ranges and disease types. To address this proposition, we present an overview of the performance of PRS tools (ie, models and sets of single nucleotide polymorphisms) alongside harms and benefits of PRS-stratified cancer screening for eight example cancers (breast, prostate, colorectal, pancreas, ovary, kidney, lung, and testicular cancer). ⋯ The Wellcome Trust.