Heart, lung & circulation
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Heart, lung & circulation · May 2016
Randomized Controlled Trial Multicenter StudyPulmonary Protective Effects of Remote Ischaemic Preconditioning with Postconditioning in Patients undergoing Cardiac Surgery involving Cardiopulmonary Bypass: A substudy of the Remote Ischaemic Preconditioning with Postconditioning Outcome trial.
The RISPO (Remote Ischemic Preconditioning with Postconditioning Outcome) trial evaluated whether remote ischaemic preconditioning (RIPC) combined with remote ischaemic postconditioning (RIPostC) improves the clinical outcomes of patients undergoing cardiac surgery. This substudy of the RISPO trial aimed to evaluate the effect of RIPC with RIPostC on pulmonary function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). ⋯ In our study, RIPC-RIPostC improved the post-operative 24h PaO2/FIO2 ratio. Remote ischaemic preconditioning-Remote ischaemic postconditioning has limited and delayed pulmonary protective effects in cardiac surgery patients with CPB.
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Heart, lung & circulation · Apr 2014
Randomized Controlled TrialThe effect of tai chi on chronic obstructive pulmonary disease: a pilot randomised study of lung function, exercise capacity and diaphragm strength.
Although the benefits of exercise on the health of patients with chronic obstructive pulmonary disease (COPD) have been widely reported, the effect of Tai Chi as an alternative exercise has not been thoroughly evaluated in patients with COPD. This study reported a randomised controlled trial, which investigated the effects of Tai Chi on lung function, exercise capacity, and diaphragm strength in patients with COPD.
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Heart, lung & circulation · Jan 2014
Randomized Controlled TrialThe effect of optimising cerebral tissue oxygen saturation on markers of neurological injury during coronary artery bypass graft surgery.
Surgical revascularisation of the coronary arteries is a cornerstone of cardiothoracic surgery. Advanced age and the incidence of preoperative co-morbidity in patients presenting for coronary artery bypass graft surgery increases the potential for stroke and other perioperative outcomes. It is hypothesised that by using interventions during cardiac surgery to improve cerebral oxygenation, the risk of patients enduring adverse neurological outcomes would be reduced. ⋯ Monitoring brain oxygen saturation during on-pump CABG together with an effective treatment protocol to deal with cerebral desaturation must be advocated.
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Heart, lung & circulation · May 2013
Randomized Controlled TrialDoes glutamine promote benefits for patients with diabetes mellitus scheduled for cardiac surgery?
We hypothesised, that perioperative use of N(2)-L-alanyl-L-glutamine confers cardioprotection and improves insulin resistance in diabetic patients with coronary artery disease operated under cardiopulmonary bypass. ⋯ Our results have failed to confirm the cardioprotective properties and modulatory effect on perioperative insulin resistance that are thought to be attributable to parenteral glutamine administration in dose 0.4 g/kg/day among cardiac patients with DM operated on under CPB.
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Heart, lung & circulation · Nov 2012
Randomized Controlled TrialCan topical application of tranexamic acid reduce blood loss in thoracic surgery? A prospective randomised double blind investigation.
The systemic or topical use of antifibrinolytic agents is effective in reducing postoperative bleeding and blood product transfusion in cardiac surgery. We sought to study the effect of the topical application of tranexamic acid into the pleural space to reduce postoperative bleeding after lung surgery. ⋯ In our experience, the topical use of tranexamic-acid after lung surgery reduces postoperative bleeding and blood transfusion volume. The topical administration of tranexamic-acid is safe without increasing the risk of post-operative complications related to pharmacological side-effects.