Revista de saúde pública
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Revista de saúde pública · Oct 2004
Randomized Controlled Trial Comparative Study Clinical TrialImmunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial.
To compare the immunogenicity of three yellow fever vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots). ⋯ The equivalent immunogenicity of yellow fever vaccines from the 17D and 17DD substrains was demonstrated for the first time in placebo-controlled double-blind randomized trial. The study completed the clinical validation process of a new vaccine seed-lot, provided evidence for use of alternative attenuated virus substrains in vaccine production for a major manufacturer, and for the utilization of the 17DD vaccine in other countries.