Articles: pain.
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Meta Analysis Comparative Study
Functional brain imaging of placebo analgesia: methodological challenges and recommendations.
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A pain relief score 50% of the maximum is often used as a clinically meaningful outcome in meta-analyses of analgesic trials. This arbitrary value requires validation. ⋯ The analysis suggests that the arbitrary 50% cut-off point TOTPAR score often used in meta-analyses of analgesic trials in dental pain is reasonably acceptable. This is different to the 33% cut-off point reported for analgesic trials of acute breakthrough cancer pain and some chronic pain states such as diabetic neuropathy and postherpetic neuralgia. These differences deserve careful consideration when reading reports of analgesic trials and meta-analyses. Remedication itself should be considered as the preferred outcome measure for analgesic trials.
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Review Meta Analysis
Are manual therapies effective in reducing pain from tension-type headache?: a systematic review.
A systematic review was performed to establish whether manual therapies have specific efficacy in reducing pain from tension-type headache (TTH). ⋯ The authors found no rigorous evidence that manual therapies have a positive effect in the evolution of TTH. The most urgent need for further research is to establish the efficacy beyond placebo of the different manual therapies currently applied in patients with TTH.
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Otolaryngol Head Neck Surg · Feb 2006
Meta AnalysisSteroids for post-tonsillectomy pain reduction: meta-analysis of randomized controlled trials.
To determine whether meta-analysis supports the use of corticosteroids to reduce post-tonsillectomy pain for pediatric patients. ⋯ A single, intraoperative dose of dexamethasone may reduce post-tonsillectomy pain on postoperative day 1, by a factor of 1 on a 10-point pain scale. As the side effects and cost of dexamethasone dose appear negligible, consideration of routine use seems reasonable.
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Cochrane Db Syst Rev · Jan 2006
Review Meta AnalysisEpidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery.
Epidural analgesia offers greater pain relief compared to systemic opioid-based medications, but its effect on morbidity and mortality is unclear. ⋯ Epidural analgesia provides better pain relief (especially during movement) for up to three postoperative days. It reduces the duration of postoperative tracheal intubation by roughly 20%. The occurrence of prolonged postoperative mechanical ventilation, overall cardiac complication, myocardial infarction, gastric complication and renal complication was also reduced by epidural analgesia, especially thoracic. However, current evidence does not confirm the beneficial effect of epidural analgesia on postoperative mortality and other types of complications.