Trending Articles
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To evaluate the clinical characteristics and outcomes of critically ill cancer patients with septic shock. ⋯ The variables associated with increased mortality were the degree of organ dysfunction determined by SOFA score at ICU admission and PS≥2.
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To evaluate the efficacy of the protocol-directed weaning from a mechanical ventilator compared to physician-directed weaning. ⋯ Protocol-directed weaning proved to have more efficacy in weaning patients from a ventilator than physician-directed weaning in terms of weaning duration and ICU length of stay without a deteriorating effect to the patients.
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J Natl Black Nurses Assoc · Jan 2000
Comparative StudyPsychological factors influencing cardiovascular risk reduction behavior in low and middle income African-American women.
Cardiovascular disease is the number one cause of death for women, especially, African-American women in the United States. In fact, it is reported that each year, 39% of all deaths in women are from coronary heart disease (CHD). Further, 1 out of every 5 women in the United States have some form of cardiovascular disease (CVD). ⋯ Findings revealed that self-efficacy to diet and exercise were positively correlated with cardiovascular risk reduction behavior in both groups. Additionally, middle-income women with higher levels of self-concept and lower body mass index were more likely to participate in the risk reduction behavior. Findings have implications for tailoring cardiovascular risk reduction interventions to African-American women of varying socioeconomic status (SES).
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BMC medical imaging · Aug 2010
Rapid T1 quantification based on 3D phase sensitive inversion recovery.
In Contrast Enhanced Magnetic Resonance Imaging fibrotic myocardium can be distinguished from healthy tissue using the difference in the longitudinal T1 relaxation after administration of Gadolinium, the so-called Late Gd Enhancement. The purpose of this work was to measure the myocardial absolute T1 post-Gd from a single breath-hold 3D Phase Sensitivity Inversion Recovery sequence (PSIR). Equations were derived to take the acquisition and saturation effects on the magnetization into account. ⋯ The method provides a robust quantification of post-Gd T1 relaxation for a complete cardiac volume within a single breath-hold.
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Biochim. Biophys. Acta · Jan 2010
Energetic performance is improved by specific activation of K+ fluxes through K(Ca) channels in heart mitochondria.
Mitochondrial volume regulation depends on K+ movement across the inner membrane and a mitochondrial Ca2+-dependent K+ channel (mitoK(Ca)) reportedly contributes to mitochondrial K+ uniporter activity. Here we utilize a novel K(Ca) channel activator, NS11021, to examine the role of mitoK(Ca) in regulating mitochondrial function by measuring K+ flux, membrane potential (DeltaPsi(m)), light scattering, and respiration in guinea pig heart mitochondria. K+ uptake and the influence of anions were assessed in mitochondria loaded with the K+ sensor PBFI by adding either the chloride (KCl), acetate (KAc), or phosphate (KH2PO4) salts of K+ to energized mitochondria in a sucrose-based medium. ⋯ Fifty nanomolar of NS11021 increased the mitochondrial respiratory control ratio (RCR) in KH2PO4, but not in KCl; however, above 1 microM, NS11021 decreased RCR and depolarized DeltaPsi(m). A control compound lacking K(Ca) activator properties did not increase K+ uptake or volume but had similar nonspecific (toxin-insensitive) effects at high concentrations. The results indicate that activating K+ flux through mitoK(Ca) mediates a beneficial effect on energetics that depends on mitochondrial swelling with maintained DeltaPsi(m).