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Randomized Controlled Trial Multicenter Study
Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial.
Regional anaesthesia-analgesia (paravertebral block + propofol) does not reduce breast cancer recurrence or chronic pain when compared to volatile anaesthesia (sevoflurane).
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Review
Restrictive fluid management strategies and outcomes in liver transplantation: a systematic review.
Restrictive fluid management strategies have been proposed to reduce complications in liver transplant recipients. We conducted a systematic review to evaluate the effects of restrictive perioperative fluid management strategies, compared with liberal ones, on postoperative outcomes in adult liver transplant recipients. Our primary outcome was acute kidney injury (AKI). Our secondary outcomes were bleeding, mortality, and other postoperative complications. ⋯ Based on low or very low levels of evidence, we did not find any association between restrictive fluid management strategies and AKI, but we observed possible protective effects of intraoperative restrictive fluid management strategies on other outcomes.
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Cochrane Db Syst Rev · Jan 2014
Review Meta AnalysisDihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria.
The World Health Organization (WHO) recommends Artemisinin-based Combination Therapy (ACT) for treating uncomplicated Plasmodium falciparum malaria. This review aims to assist the decision-making of malaria control programmes by providing an overview of the relative effects of dihydroartemisinin-piperaquine (DHA-P) versus other recommended ACTs. ⋯ In Africa, dihydroartemisinin-piperaquine reduces overall treatment failure compared to artemether-lumefantrine, although both drugs have PCR-adjusted failure rates of less than 5%. In Asia, dihydroartemisinin-piperaquine is as effective as artesunate plus mefloquine, and is better tolerated.
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Spinal anaesthesia should not be performed above the L3/4 interspace if relying on surface anatomy to determine spinal level.
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