• Postoperative mortality and intraoperative anesthetic depth


    Daniel Jolley.

    6 articles.

    Created January 1, 2016, last updated over 1 year ago.

    Collection: 67, Score: 2090, Trend score: 0, Read count: 2106, Articles count: 6, Created: 2016-01-01 02:49:20 UTC. Updated: 2021-11-03 22:48:51 UTC.



    There has been some observational evidence that a greater depth of anesthesia, as measured by BIS, may be associated with an increase in post-operative mortality. In particular the association of the "triple low state" (low BIS, low volatile-ET, low MAP) with post-operative mortality is worrying.

    Completion of the Balanced Anaesthesia Study Group’s large RCT looking at this issue however brings us as close to a final word as we may expect. Short et al. (2019) showed no difference in 1-year mortality for older patients undergoing major surgery, whether they received a deep (BIS target 35) or light (BIS target 50) general anaesthetic.

    It is likely that earlier observational studies were showing the consequences of intraoperative hypotension resulting from anaesthetic depth, rather than anaesthetic depth itself.

    Daniel Jolley  Daniel Jolley
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